{"symbol":"LGR5","synonyms":["GRP49","FEX","GPR49","HG38","GPR67"],"name":"leucine-rich repeat containing G protein-coupled receptor 5","description":"The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]","ncbiEntrezGeneId":8549,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8549","proteins":[{"symbol":"LGR5_HUMAN","href":"/api/1.0/protein/LGR5_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}