{"symbol":"LIAS","synonyms":["HGCLAS","HUSSY-01","PDHLD","LS","LAS"],"name":"lipoic acid synthetase","description":"The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":11019,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11019","proteins":[{"symbol":"LIAS_HUMAN","href":"/api/1.0/protein/LIAS_HUMAN"}],"hgncRootFamilies":[]}