{"symbol":"LIG1","synonyms":[],"name":"ligase I, DNA, ATP-dependent","description":"This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]","ncbiEntrezGeneId":3978,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3978","proteins":[{"symbol":"DNLI1_HUMAN","href":"/api/1.0/protein/DNLI1_HUMAN"}],"hgncRootFamilies":[]}