{"symbol":"LILRB5","synonyms":["LIR-8","LIR8","CD85C"],"name":"leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5","description":"This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10990,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10990","proteins":[{"symbol":"LIRB5_HUMAN","href":"/api/1.0/protein/LIRB5_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}