{"symbol":"LITAF","synonyms":["TP53I7","SIMPLE","PIG7"],"name":"lipopolysaccharide-induced TNF factor","description":"Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget\u0027s disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]","ncbiEntrezGeneId":9516,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9516","proteins":[{"symbol":"LITAF_HUMAN","href":"/api/1.0/protein/LITAF_HUMAN"}],"hgncRootFamilies":[]}