{"symbol":"LLGL2","synonyms":["HUGL-2","LGL2"],"name":"lethal giant larvae homolog 2 (Drosophila)","description":"The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein\u0027s ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3993,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3993","proteins":[{"symbol":"L2GL2_HUMAN","href":"/api/1.0/protein/L2GL2_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}