{"symbol":"LMTK2","synonyms":["KPI2","PPP1R100","hBREK","CPRK","AATYK2","KPI-2","BREK","LMR2"],"name":"lemur tyrosine kinase 2","description":"The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":22853,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22853","proteins":[{"symbol":"LMTK2_HUMAN","href":"/api/1.0/protein/LMTK2_HUMAN"}],"hgncRootFamilies":[{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"},{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}