{"symbol":"LONP2","synonyms":["PLON","PSLON","LONPL"],"name":"lon peptidase 2, peroxisomal","description":"In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]","ncbiEntrezGeneId":83752,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/83752","proteins":[{"symbol":"LONP2_HUMAN","href":"/api/1.0/protein/LONP2_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}