{"symbol":"LOX","synonyms":["AAT10"],"name":"lysyl oxidase","description":"This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":4015,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4015","proteins":[{"symbol":"LYOX_HUMAN","href":"/api/1.0/protein/LYOX_HUMAN"}],"hgncRootFamilies":[]}