{"symbol":"LOXL4","synonyms":["LOXC"],"name":"lysyl oxidase-like 4","description":"This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":84171,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/84171","proteins":[{"symbol":"LOXL4_HUMAN","href":"/api/1.0/protein/LOXL4_HUMAN"}],"hgncRootFamilies":[]}