{"symbol":"LRBA","synonyms":["LBA","CVID8","LAB300","BGL","CDC4L"],"name":"LPS-responsive vesicle trafficking, beach and anchor containing","description":"The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]","ncbiEntrezGeneId":987,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/987","proteins":[{"symbol":"LRBA_HUMAN","href":"/api/1.0/protein/LRBA_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}