{"symbol":"LRP6","synonyms":["ADCAD2","STHAG7"],"name":"low density lipoprotein receptor-related protein 6","description":"This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]","ncbiEntrezGeneId":4040,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4040","proteins":[{"symbol":"LRP6_HUMAN","href":"/api/1.0/protein/LRP6_HUMAN"}],"hgncRootFamilies":[{"name":"Low density lipoprotein receptors","href":"/api/1.0/gene_family/Low+density+lipoprotein+receptors"}]}