{"symbol":"LRP8","synonyms":["MCI1","APOER2","HSZ75190","LRP-8"],"name":"low density lipoprotein receptor-related protein 8, apolipoprotein e receptor","description":"This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]","ncbiEntrezGeneId":7804,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7804","proteins":[{"symbol":"LRP8_HUMAN","href":"/api/1.0/protein/LRP8_HUMAN"}],"hgncRootFamilies":[{"name":"Low density lipoprotein receptors","href":"/api/1.0/gene_family/Low+density+lipoprotein+receptors"}]}