{"symbol":"LRRFIP2","synonyms":["HUFI-2"],"name":"leucine rich repeat (in FLII) interacting protein 2","description":"The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]","ncbiEntrezGeneId":9209,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9209","proteins":[{"symbol":"LRRF2_HUMAN","href":"/api/1.0/protein/LRRF2_HUMAN"}],"hgncRootFamilies":[]}