{"symbol":"LRRK2","synonyms":["PARK8","DARDARIN","AURA17","ROCO2","RIPK7"],"name":"leucine-rich repeat kinase 2","description":"This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":120892,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/120892","proteins":[{"symbol":"LRRK2_HUMAN","href":"/api/1.0/protein/LRRK2_HUMAN"}],"hgncRootFamilies":[{"name":"Parkinson disease associated genes (PARK)","href":"/api/1.0/gene_family/Parkinson+disease+associated+genes+%28PARK%29"}]}