{"symbol":"LSM1","synonyms":["CASM","YJL124C"],"name":"LSM1, U6 small nuclear RNA associated","description":"This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3\u0027-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]","ncbiEntrezGeneId":27257,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27257","proteins":[{"symbol":"LSM1_HUMAN","href":"/api/1.0/protein/LSM1_HUMAN"}],"hgncRootFamilies":[]}