{"symbol":"LTA","synonyms":["TNFSF1","TNFB","LT","TNLG1E"],"name":"lymphotoxin alpha","description":"The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin\u0027s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":4049,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4049","proteins":[{"symbol":"TNFB_HUMAN","href":"/api/1.0/protein/TNFB_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor (ligand) superfamily (TNFSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+%28ligand%29+superfamily+%28TNFSF%29"}]}