{"symbol":"LTB","synonyms":["TNFC","TNFSF3","TNLG1C"],"name":"lymphotoxin beta (TNF superfamily, member 3)","description":"Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4050,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4050","proteins":[{"symbol":"TNFC_HUMAN","href":"/api/1.0/protein/TNFC_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor (ligand) superfamily (TNFSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+%28ligand%29+superfamily+%28TNFSF%29"}]}