{"symbol":"MANF","synonyms":["ARMET"],"name":"mesencephalic astrocyte-derived neurotrophic factor","description":"The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":7873,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7873","proteins":[{"symbol":"MANF_HUMAN","href":"/api/1.0/protein/MANF_HUMAN"}],"hgncRootFamilies":[]}