{"symbol":"MAP2K7","synonyms":["MEK","MAPKK7","MEK 7","SAPKK-4","MKK7","SAPKK4","PRKMK7","JNKK2"],"name":"mitogen-activated protein kinase kinase 7","description":"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]","ncbiEntrezGeneId":5609,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5609","proteins":[{"symbol":"MP2K7_HUMAN","href":"/api/1.0/protein/MP2K7_HUMAN"}],"hgncRootFamilies":[{"name":"Mitogen-activated protein kinase cascade","href":"/api/1.0/gene_family/Mitogen-activated+protein+kinase+cascade"}]}