{"symbol":"MAP3K1","synonyms":["SRXY6","MEKK1","MEKK","MAPKKK1","MEKK 1"],"name":"mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase","description":"The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":4214,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4214","proteins":[{"symbol":"M3K1_HUMAN","href":"/api/1.0/protein/M3K1_HUMAN"}],"hgncRootFamilies":[{"name":"Mitogen-activated protein kinase cascade","href":"/api/1.0/gene_family/Mitogen-activated+protein+kinase+cascade"}]}