{"symbol":"MAP3K7","synonyms":["CSCF","TAK1","TGF1A","FMD2","MEKK7"],"name":"mitogen-activated protein kinase kinase kinase 7","description":"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6885,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6885","proteins":[{"symbol":"M3K7_HUMAN","href":"/api/1.0/protein/M3K7_HUMAN"}],"hgncRootFamilies":[{"name":"Mitogen-activated protein kinase cascade","href":"/api/1.0/gene_family/Mitogen-activated+protein+kinase+cascade"}]}