{"symbol":"MAP4","synonyms":[],"name":"microtubule-associated protein 4","description":"The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]","ncbiEntrezGeneId":4134,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4134","proteins":[{"symbol":"MAP4_HUMAN","href":"/api/1.0/protein/MAP4_HUMAN"}],"hgncRootFamilies":[]}