{"symbol":"MAP4K2","synonyms":["BL44","GCK","RAB8IP"],"name":"mitogen-activated protein kinase kinase kinase kinase 2","description":"The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":5871,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5871","proteins":[{"symbol":"M4K2_HUMAN","href":"/api/1.0/protein/M4K2_HUMAN"}],"hgncRootFamilies":[{"name":"Mitogen-activated protein kinase cascade","href":"/api/1.0/gene_family/Mitogen-activated+protein+kinase+cascade"}]}