{"symbol":"MAP4K4","synonyms":["MEKKK4","HEL-S-31","FLH21957","HGK"],"name":"mitogen-activated protein kinase kinase kinase kinase 4","description":"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9448,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9448","proteins":[{"symbol":"M4K4_HUMAN","href":"/api/1.0/protein/M4K4_HUMAN"}],"hgncRootFamilies":[{"name":"Mitogen-activated protein kinase cascade","href":"/api/1.0/gene_family/Mitogen-activated+protein+kinase+cascade"}]}