{"symbol":"MAPK10","synonyms":["SAPK1B","P54BSAPK","P493F12","PRKM10","JNK3","JNK3A"],"name":"mitogen-activated protein kinase 10","description":"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]","ncbiEntrezGeneId":5602,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5602","proteins":[{"symbol":"MK10_HUMAN","href":"/api/1.0/protein/MK10_HUMAN"}],"hgncRootFamilies":[{"name":"Mitogen-activated protein kinase cascade","href":"/api/1.0/gene_family/Mitogen-activated+protein+kinase+cascade"}]}