{"symbol":"MAPK8IP1","synonyms":["JIP-1","JIP1","IB1","PRKM8IP"],"name":"mitogen-activated protein kinase 8 interacting protein 1","description":"This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]","ncbiEntrezGeneId":9479,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9479","proteins":[{"symbol":"JIP1_HUMAN","href":"/api/1.0/protein/JIP1_HUMAN"}],"hgncRootFamilies":[]}