{"symbol":"MARCH11","synonyms":["MARCH-XI","RNF226"],"name":"membrane-associated ring finger (C3HC4) 11","description":"MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]","ncbiEntrezGeneId":441061,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/441061","proteins":[{"symbol":"MARHB_HUMAN","href":"/api/1.0/protein/MARHB_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}