{"symbol":"MASP1","synonyms":["MASP","MASP3","CRARF","MAP44","MAP1","3MC1","PRSS5","CRARF1"],"name":"mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)","description":"This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]","ncbiEntrezGeneId":5648,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5648","proteins":[{"symbol":"MASP1_HUMAN","href":"/api/1.0/protein/MASP1_HUMAN"}],"hgncRootFamilies":[{"name":"Proteases, serine (PRSS)","href":"/api/1.0/gene_family/Proteases%2C+serine+%28PRSS%29"}]}