{"symbol":"MAT1A","synonyms":["MATA1","SAMS1"],"name":"methionine adenosyltransferase I, alpha","description":"This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4143,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4143","proteins":[{"symbol":"METK1_HUMAN","href":"/api/1.0/protein/METK1_HUMAN"}],"hgncRootFamilies":[]}