{"symbol":"MATK","synonyms":["HYLTK","HYL","CTK","HHYLTK"],"name":"megakaryocyte-associated tyrosine kinase","description":"The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4145,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4145","proteins":[{"symbol":"MATK_HUMAN","href":"/api/1.0/protein/MATK_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}