{"symbol":"MBD1","synonyms":["PCM1","RFT","CXXC3"],"name":"methyl-CpG binding domain protein 1","description":"The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]","ncbiEntrezGeneId":4152,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4152","proteins":[{"symbol":"MBD1_HUMAN","href":"/api/1.0/protein/MBD1_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}