{"symbol":"MC2R","synonyms":["ACTHR"],"name":"melanocortin 2 receptor (adrenocorticotropic hormone)","description":"MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]","ncbiEntrezGeneId":4158,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4158","proteins":[{"symbol":"ACTHR_HUMAN","href":"/api/1.0/protein/ACTHR_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}