{"symbol":"MCF2L","synonyms":["ARHGEF14"],"name":"MCF.2 cell line derived transforming sequence-like","description":"This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":23263,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23263","proteins":[{"symbol":"MCF2L_HUMAN","href":"/api/1.0/protein/MCF2L_HUMAN"}],"hgncRootFamilies":[{"name":"Rho guanine nucleotide exchange factors (ARHGEF)","href":"/api/1.0/gene_family/Rho+guanine+nucleotide+exchange+factors+%28ARHGEF%29"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}