{"symbol":"MDC1","synonyms":["NFBD1"],"name":"mediator of DNA-damage checkpoint 1","description":"The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9656,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9656","proteins":[{"symbol":"MDC1_HUMAN","href":"/api/1.0/protein/MDC1_HUMAN"}],"hgncRootFamilies":[]}