{"symbol":"MDM2","synonyms":["HDM2","ACTFS","HDMX"],"name":"MDM2 proto-oncogene, E3 ubiquitin protein ligase","description":"This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]","ncbiEntrezGeneId":4193,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4193","proteins":[{"symbol":"MDM2_HUMAN","href":"/api/1.0/protein/MDM2_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}