{"symbol":"ME3","synonyms":["NADP-ME"],"name":"malic enzyme 3, NADP(+)-dependent, mitochondrial","description":"Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10873,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10873","proteins":[{"symbol":"MAON_HUMAN","href":"/api/1.0/protein/MAON_HUMAN"}],"hgncRootFamilies":[]}