{"symbol":"MED17","synonyms":["TRAP80","DRIP80","CRSP6","SRB4","CRSP77"],"name":"mediator complex subunit 17","description":"The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9440,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9440","proteins":[{"symbol":"MED17_HUMAN","href":"/api/1.0/protein/MED17_HUMAN"}],"hgncRootFamilies":[]}