{"symbol":"MED26","synonyms":["CRSP70","CRSP7"],"name":"mediator complex subunit 26","description":"The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9441,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9441","proteins":[{"symbol":"MED26_HUMAN","href":"/api/1.0/protein/MED26_HUMAN"}],"hgncRootFamilies":[]}