{"symbol":"MEPE","synonyms":["OF45"],"name":"matrix extracellular phosphoglycoprotein","description":"This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]","ncbiEntrezGeneId":56955,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56955","proteins":[{"symbol":"MEPE_HUMAN","href":"/api/1.0/protein/MEPE_HUMAN"}],"hgncRootFamilies":[]}