{"symbol":"MFNG","synonyms":[],"name":"MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase","description":"This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018]","ncbiEntrezGeneId":4242,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4242","proteins":[{"symbol":"MFNG_HUMAN","href":"/api/1.0/protein/MFNG_HUMAN"}],"hgncRootFamilies":[{"name":"Glycosyltransferases","href":"/api/1.0/gene_family/Glycosyltransferases"}]}