{"symbol":"MICU1","synonyms":["CALC","EFHA3","ara CALC","CBARA1","MPXPS"],"name":"mitochondrial calcium uptake 1","description":"This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]","ncbiEntrezGeneId":10367,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10367","proteins":[{"symbol":"MICU1_HUMAN","href":"/api/1.0/protein/MICU1_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}