{"symbol":"MKL1","synonyms":["MKL","BSAC","MRTF-A","MAL","MRTFA"],"name":"megakaryoblastic leukemia (translocation) 1","description":"The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]","ncbiEntrezGeneId":57591,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/57591","proteins":[{"symbol":"MKL1_HUMAN","href":"/api/1.0/protein/MKL1_HUMAN"}],"hgncRootFamilies":[]}