{"symbol":"MNT","synonyms":["MXD6","MAD6","BHLHD3","ROX"],"name":"MAX network transcriptional repressor","description":"The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4335,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4335","proteins":[{"symbol":"MNT_HUMAN","href":"/api/1.0/protein/MNT_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"},{"name":"MAX dimerization proteins (MXD)","href":"/api/1.0/gene_family/MAX+dimerization+proteins+%28MXD%29"}]}