{"symbol":"MOGS","synonyms":["DER7","CWH41","GCS1","CDG2B"],"name":"mannosyl-oligosaccharide glucosidase","description":"This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":7841,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7841","proteins":[{"symbol":"MOGS_HUMAN","href":"/api/1.0/protein/MOGS_HUMAN"}],"hgncRootFamilies":[]}