{"symbol":"MRE11A","synonyms":["MRE11B","ATLD","MRE11","HNGS1"],"name":"MRE11 meiotic recombination 11 homolog A (S. cerevisiae)","description":"This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3\u0027 to 5\u0027 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3\u0027 to 5\u0027 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4361,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4361","proteins":[{"symbol":"MRE11_HUMAN","href":"/api/1.0/protein/MRE11_HUMAN"}],"hgncRootFamilies":[]}