{"symbol":"MRPL12","synonyms":["MRPL7","5C5-2","RPML12","L12MT","MRPL7/L12","MRP-L31/34"],"name":"mitochondrial ribosomal protein L12","description":"Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6182,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6182","proteins":[{"symbol":"RM12_HUMAN","href":"/api/1.0/protein/RM12_HUMAN"}],"hgncRootFamilies":[{"name":"Mitochondrial ribosomal proteins (MRPL, MRPS)","href":"/api/1.0/gene_family/Mitochondrial+ribosomal+proteins+%28MRPL%2C+MRPS%29"}]}