{"symbol":"MRPS11","synonyms":["HCC-2","MRP-S11","S11mt"],"name":"mitochondrial ribosomal protein S11","description":"Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]","ncbiEntrezGeneId":64963,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64963","proteins":[{"symbol":"RT11_HUMAN","href":"/api/1.0/protein/RT11_HUMAN"}],"hgncRootFamilies":[{"name":"Mitochondrial ribosomal proteins (MRPL, MRPS)","href":"/api/1.0/gene_family/Mitochondrial+ribosomal+proteins+%28MRPL%2C+MRPS%29"}]}