{"symbol":"MRPS22","synonyms":["GK002","ODG7","MRP-S22","GIBT","C3ORF5","COXPD5","RPMS22"],"name":"mitochondrial ribosomal protein S22","description":"Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":56945,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56945","proteins":[{"symbol":"RT22_HUMAN","href":"/api/1.0/protein/RT22_HUMAN"}],"hgncRootFamilies":[{"name":"Mitochondrial ribosomal proteins (MRPL, MRPS)","href":"/api/1.0/gene_family/Mitochondrial+ribosomal+proteins+%28MRPL%2C+MRPS%29"}]}