{"symbol":"MS4A2","synonyms":["IGHER","APY","IGEL","IGER","ATOPY","FCER1B","MS4A1"],"name":"membrane-spanning 4-domains, subfamily A, member 2","description":"The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":2206,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2206","proteins":[{"symbol":"FCERB_HUMAN","href":"/api/1.0/protein/FCERB_HUMAN"}],"hgncRootFamilies":[]}